| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
Review |
1 Institute for Pathology, Friedrich-Alexander-University, Krankenhausstr. 8–10, 91054 Erlangen, Germany
Correspondence: Dr Niedobitek gerald.niedobitek{at}patho.imed.uni-erlangen.de
The association of nasopharyngeal carcinoma (NPC) with the Epstein-Barr virus (EBV) was firmly established as early as 1973. Nevertheless, the role for the virus in the pathogenesis of NPC is still controversial. In this article, the evidence implicating EBV in the development of NPC is reviewed, focusing on the cellular site of EBV persistence, the association of the virus with different NPC histotypes, the tumour cell phenotype in the context of viral latent gene expression, and the possible role of the lymphoid stroma.
Key Words: Epstein-Barr virus • nasopharyngeal carcinoma • viral latent gene expression
This article has been cited by other articles:
|
|
 |
|
  C.-L. Tsai, H.-P. Li, Y.-J. Lu, C. Hsueh, Y. Liang, C.-L. Chen, S. W. Tsao, K.-P. Tse, J.-S. Yu, and Y.-S. Chang Activation of DNA Methyltransferase 1 by EBV LMP1 Involves c-Jun NH2-Terminal Kinase Signaling Cancer Res., December 15, 2006; 66(24): 11668 - 11676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Tai, M. Lin, F. Chang, G. Chen, F. Hsiao, N. Sutkowski, and B. T. Huber Murine Vbeta3+ and Vbeta7+ T Cell Subsets Are Specific Targets for the HERV-K18 Env Superantigen. J. Immunol., September 1, 2006; 177(5): 3178 - 3184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Straathof, A. M. Leen, E. L. Buza, G. Taylor, M. H. Huls, H. E. Heslop, C. M. Rooney, and C. M. Bollard Characterization of Latent Membrane Protein 2 Specificity in CTL Lines from Patients with EBV-Positive Nasopharyngeal Carcinoma and Lymphoma J. Immunol., September 15, 2005; 175(6): 4137 - 4147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-T. Le, C. D. Jones, T.-K. Yau, H. A. Shirazi, P. H. Wong, E. N. Thomas, B. K. Patterson, A. W.M. Lee, and J. L. Zehnder A Comparison Study of Different PCR Assays in Measuring Circulating Plasma Epstein-Barr Virus DNA Levels in Patients with Nasopharyngeal Carcinoma Clin. Cancer Res., August 15, 2005; 11(16): 5700 - 5707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. C. Stevens, S. A. W. M. Verkuijlen, B. Hariwiyanto, Harijadi, J. Fachiroh, D. K. Paramita, I. B. Tan, S. M. Haryana, and J. M. Middeldorp Diagnostic Value of Measuring Epstein-Barr Virus (EBV) DNA Load and Carcinoma-Specific Viral mRNA in Relation to Anti-EBV Immunoglobulin A (IgA) and IgG Antibody Levels in Blood of Nasopharyngeal Carcinoma Patients from Indonesia J. Clin. Microbiol., July 1, 2005; 43(7): 3066 - 3073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Stambuk, S. G. Patel, K. M. Mosier, S. L. Wolden, and A. I. Holodny Nasopharyngeal Carcinoma: Recognizing the Radiographic Features in Children AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1575 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. M. Straathof, C. M. Bollard, U. Popat, M. H. Huls, T. Lopez, M. C. Morriss, M. V. Gresik, A. P. Gee, H. V. Russell, M. K. Brenner, et al. Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes Blood, March 1, 2005; 105(5): 1898 - 1904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhang, J. Zhang, Q. Lambert, C. J. Der, L. Del Valle, J. Miklossy, K. Khalili, Y. Zhou, and J. S. Pagano Interferon Regulatory Factor 7 Is Associated with Epstein-Barr Virus-Transformed Central Nervous System Lymphoma and Has Oncogenic Properties J. Virol., December 1, 2004; 78(23): 12987 - 12995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Cheung, M.-t. Ling, S. W. Tsao, Y.C. Wong, and X. Wang Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells Carcinogenesis, June 1, 2004; 25(6): 881 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C.M. Straathof, C. M. Bollard, C. M. Rooney, and H. E. Heslop Immunotherapy for Epstein-Barr Virus-Associated Cancers in Children Oncologist, February 1, 2003; 8(1): 83 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lu, H.-H. Chua, S.-Y. Chen, J.-Y. Chen, and C.-H. Tsai Regulation of Matrix Metalloproteinase-1 by Epstein-Barr Virus Proteins Cancer Res., January 1, 2003; 63(1): 256 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gius and C. N. Coleman Treatment of Nasopharyngeal Cancer: Raising the "Barr" J Natl Cancer Inst, November 6, 2002; 94(21): 1594 - 1595. [Full Text] [PDF]
|
|
|
|
|
|
T. Sze Wong, H. Wen Chang, K. Chi Tang, W. Ignace Wei, D. Lai Wen Kwong, J. Shun Tong Sham, A. Po Wing Yuen, and Y. Lam Kwong High Frequency of Promoter Hypermethylation of the Death-associated Protein-Kinase Gene in Nasopharyngeal Carcinoma and Its Detection in the Peripheral Blood of Patients Clin. Cancer Res., February 1, 2002; 8(2): 433 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P G Murray and L S Young Themed issue: the biology and pathology of the Epstein-Barr virus Mol. Pathol., October 1, 2000; 53(5): 219 - 221. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| Molecular Pathology | Journal of Clinical Pathology |
