Register for email alerts and news feeds:
This journal | BMJ Group
rss
Molecular Pathology 2000;53:262-269; doi:10.1136/mp.53.5.262
Copyright © 2000 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.
J Clin Pathol: Mol Pathol 2000; 53:262-269
© 2000 Journal of Clinical Pathology

Review

Hodgkin's disease and the Epstein-Barr virus

K J Flavell2 and P G Murray1

1 The School of Health Sciences, University of Wolverhampton, Wolverhampton WV1 1DJ, UK
2 The Department of Pathology, Division of Cancer Studies, Medical School, University of Birmingham, Birmingham B15 2TT, UK

Correspondence to:
Dr Murray p.g.murray{at}bham.ac.uk

Hodgkin's disease is an unusual cancer because the malignant cells constitute only a minority of the total tumour mass and, as a consequence, the study of these cells has been a major challenge. Recently, the application of newer technologies, such as single cell polymerase chain reaction (PCR) and gene expression array analysis, to the study of Hodgkin's disease have yielded new insights into the pathogenesis of this tumour. In addition, the recognition that a proportion of Hodgkin's disease tumours harbour the Epstein-Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of Hodgkin's disease in some cases. This review summarises current knowledge of the pathogenesis of Hodgkin's disease with particular emphasis on the association with EBV. J Clin Pathol: Mol Pathol

Key Words: Hodgkin's disease • Epstein-Barr virus • Hodgkin-Reed Sternberg cells


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • Niens, M., van den Berg, A., Diepstra, A., Nolte, I. M., van der Steege, G., Gallagher, A., Taylor, G. M., Jarrett, R. F., Poppema, S., te Meerman, G. J. (2006). The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate Genes.. Cancer Epidemiol. Biomarkers Prev. 15: 2280-2284 [Abstract] [Full Text]  
  • Lemke, C. D., Haynes, J. S., Spaete, R., Adolphson, D., Vorwald, A., Lager, K., Butler, J. E. (2004). Lymphoid Hyperplasia Resulting in Immune Dysregulation Is Caused by Porcine Reproductive and Respiratory Syndrome Virus Infection in Neonatal Pigs. J. Immunol. 172: 1916-1925 [Abstract] [Full Text]  
  • Murray, P G, Young, L S (2000). Themed issue: the biology and pathology of the Epstein-Barr virus. Mol. Pathol. 53: 219-221 [Full Text]  

Pathology jobs

Pathology jobs