© 2002 Journal of Clinical Pathology
REVIEW
Methods of molecular analysis: assessing losses and gains in tumours
Correspondence to:
Correspondence to:
R Roylance, Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK;
r.roylance{at}icrf.icnet.uk
The study of chromosomal aberrations has facilitated the understanding of tumorigenesis. By applying molecular genetic techniques to regions highlighted by cytogenetic study, many genes important in tumorigenesis have been identified. This review will describe the cytogenetic and molecular cytogenetic techniques used to identify these changes. The clinical information that they can provide, including diagnostic and prognostic information, will also briefly be discussed.
Keywords: cytogenetics; fluorescence in situ hybridisation; comparative genomic hybridisation
Abbreviations: CGH, comparative genomic hybridisation; FISH, fluorescence in situ hybridisation
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Dey, P
(2004). Aneuploidy and malignancy: an unsolved equation. J. Clin. Pathol.
57: 1245-1249
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
