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Progressive supranuclear palsy

Abstract

This review concentrates on the molecular pathology of the protein τ, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant τ processing remains unclear.

  • progressive supranuclear palsy
  • neurodegenerative disease
  • oxidative stress
  • τ protein filaments

https://doi.org/10.1136/mp.54.6.427

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