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Original Article
Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue

Abstract

Background: Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori.

Aims: To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer.

Results: zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues.

Conclusions: The zFOC1 gene appears to be a tumour marker associated with gastric cancer.

  • gastric cancer
  • zFOC1
  • zinc finger protein
  • cDNA array
  • Helicobacter pylori
  • EST, expressed sequence tag
  • GAPDH, glyceraldehyde 3 phosphate dehydrogenase
  • PAI, pathogenicity island
  • RT-PCR, reverse transcription polymerase chain reaction
  • SDS, sodium dodecyl sulfate
  • SCC, saline sodium citrate
  • UTR, untranslated region

https://doi.org/10.1136/mp.56.3.167

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