Table 1

Characteristics of the monoclonal antibodies (mAbs) used for testing the reactivity of mAb 2G10

Antibody	Species	Isotype	Residues 74–79	V_H family	V_L family	Reactivity with mAb 2G10	Reference
Polar amino acids are shown in bold.
The V_H of mAb 2C7 is highly homologous to the human V_H3 gene family.¹
Antibodies A2¹² and the CDR grafted CAMPATH-1H⁹ are recombinant proteins.
2C7	Mouse	IgG2b	S K N T L Y	4	κ2	+	1
Cal-4G	Human	IgM	S K N Q F S	4-34	λ9	+	10, 11
A2	Human	IgA	S K N T L Y	3	κ10	+	12, 13
CAMPATH-1H	Human	IgG1	S K N Q F S	4	κ1	+	9
105AD7	Human	IgG1	S K N Q V V	2	κ1	_	8
MOPC-21	Mouse	IgG1	P K N T L F	2	κ19	_	14, 15
MOPC-141	Mouse	IgG2b	S K S Q V F	1	κ10	_	16, 17
YTH34.5.6	Rat	IgG2a	T Q N M L Y	2	κ1	_	9

Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins

Pathology jobs