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Mol Path 53:83-87 doi:10.1136/mp.53.2.83

Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens

Table 2

Molecular biological findings in relation to the leukaemia subtype

Immunohistochemical diagnosis Number of cases Monoclonal rearrangement %
AL, acute leukaemia; ALL, acute lymphoblastic leukaemia; AML, acute myelogenous leukaemia; B-ALL, B cell ALL; IgH, immunoglobulin heavy chain; T-ALL, T cell ALL; TCR-γ, T cell receptor γ; u-ALL, unclassified ALL.
B-ALL n = 1 1 (IgH) 100
T-ALL n = 7 5 (4 TCR-γ, 1 IgH) 71
c-ALL n = 23 21 (19 IgH, 1 IgH + TCR-γ, 1 TCR-γ) 91
u-ALL n = 4 4 (3 IgH, 1 IgH + TCR-γ) 100
ALL n = 35 31 (26 IgH, 7 TCR-γ) 89
AL, biphenotypic n = 3 2 (IgH) 67
AML n = 10 2 (IgH) 20

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