Table 3
Summary of the findings of previous studies on the association between CYP2E1 genetic polymorphisms and susceptibility to alcoholic liver disease (ALD) in white populations
| Reference | Population studied | Study group (n) | c2 allele frequency | p Value | C allele frequency | p Value |
|---|---|---|---|---|---|---|
| *Chi squared test with Yates correction; §two tailed Fisher's exact test; #healthy controls; ¶alcohol related cirrhosis; †no raw data given. | ||||||
| Ingelman-Sundberg et al (1993)3 | Italian | Control# (114) | 0.044 | 0.56§ | 0.083 | 0.22* |
| Cirrhosis¶ (56) | 0.027 | 0.036 | ||||
| Carr et al (1995)6 | North American | Control# (32) | 0.016 | 0.41§ | – | – |
| ALD (53) | 0.047 | |||||
| Ball et al (1995)7 | British | Control# (114) | 0.028 | 0.70§ | – | – |
| Cirrhosis¶ (37) | 0.041 | |||||
| Pirmohamed et al (1995)8 | British | Control# (100) | 0.015 | 0.0006* | – | – |
| ALD (95) | 0.100 | |||||
| Lucas et al (1996)9 | French | Control# (260) | 0.025 | 0.35* | 0.079 | 0.008* |
| Cirrhosis¶ (110) | 0.041 | 0.146 | ||||
| Agúndez et al (1996)10 | Spanish | Control# (137) | 0.026 | ≈ 1.00§ | – | – |
| Cirrhosis¶ (58) | 0.017 | |||||
| Savolainen (1997)11 | Finnish | No ALD (33) | † | – | 0.045 | 0.08* |
| ALD (207) | 0.010 | 0.130 | ||||
| Parsian et al (1998)12 | North American | Control# (89) | 0.011 | ≈ 1.00§ | 0.107 | 0.90* |
| Cirrhosis¶ (43) | 0.000 | 0.093 | ||||
| Grove et al (1998)13 | British | Control# (121) | 0.017 | 0.44* | – | – |
| ALD (240) | 0.029 | – | ||||
| Wong et al (current study) | British | Control# (375) | 0.033 | 0.41§ | 0.096 | 0.97* |
| ALD (61) | 0.016 | 0.090 | ||||
