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Mol Path 53:133-136 doi:10.1136/mp.53.3.133

Telomerase activity in pancreatic endocrine tumours: a potential marker for malignancy

Table 1

Clinicopathological features and telomerase activity in pancreatic endocrine tumours (PETs)

Case/Race Sex/Age Site Tumour type Size (diameter) of PETs Telomerase activity Optical density Treatment Follow up (months) Remarks
ACTH, adrenocorticotrophin; MEN 1, multiple endocrine neoplasia type 1; NED, no evidence of disease.
1/Chinese M/46 Head Insulinoma 1.5 cm Negative Enucleation 52, alive, NED
2/Chinese M/41 Multiple Insulinoma Multiple tumors, the largest one: 6.0 cm at tail Negative Distal subtotal pancreatectomy 46, alive NED Had MEN 1
3/Chinese F/43 Body Malignant ACTH producing PET 1.0 cm Positive 1.9 Distal pancreotomy 18, died Metastases in liver
4/Chinese M/22 Multiple Insulinoma Multiple tumours, the largest one: 1.0 cm at tail Positive 1.9 Distal subtotal pancreatectomy 36, alive NED Had MEN 1
5/Indian F/49 Tail Insulinoma 1.5 cm Negative Enucleation 16, alive, NED
6/Chinese M/29 Body Insulinoma 1.5 cm Negative Distal pancreatectomy 21, alive NED
7/Chinese F/64 Tail Malignant insulinoma 7.0 cm Positive 1.4 Distal pancreatectomy 15, alive with residual disease Metastases in liver
8/Chinese M/35 Tail Insulinoma 1.5 cm Negative Distal pancreatectomy 11, alive NED
9/Chinese M/68 Head Insulinoma 1.0 cm Negative Enucleation 4, alive, NED
10/Chinese F/65 Head Insulinoma 1.5 cm Negative Enucleation 3, alive, NED

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