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Mol Path 53:194-200 doi:10.1136/mp.53.4.194

Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction

Table 3

Complementarity determining region 3 (CDR3) PCR results on B cell non-Hodgkin's lymphoma

Paraffin wax embedded PCR results Fresh/frozen PCR results
n M IP P NS % Positive n M IP P NS % Positive
CLL, chronic lymphocytic leukaemia; FCBCC, follicular centroblastic/centrocytic lymphoma; IP, incomplete polyclonal pattern; M, monoclonal pattern; MALT, mucosa associated lymphoid tissue lymphoma; MCL, mantle cell lymphoma; n, number of cases; NS, no signal; P, polyclonal pattern.
CLL 9 7 0 0 2 78% 9 8 0 0 1 89%
MCL 8 7 0 0 1 88% 8 8 0 0 0 100%
MALT 35 21 10 1 3 60% 22 19 2 1 0 86%
FCBCC 10 4 0 5 1 40% 10 6 1 3 0 60%

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