Table 2
General, γ-herpesvirus specific, and virus specific genes
| Core genes (α, β, γ) | Cross subfamily generala/specificb | γ General (virus shared) | γ Specialised (virus specific) |
|---|---|---|---|
| Numbers in parentheses correspond to HVS ORF designations. | |||
| The list of core genes is not comprehensive, it gives examples only. | |||
| *These genes are not present in EHV-2 or AHV-1. | |||
| **Bcl-2 homologues present in every γ herpesvirus, but not all in same genomic locus. | |||
| ***Most γ-2 GCRs in γDL-D; EBV and ungulate γ2s (EHV-2, AHV-1) have probable GCRs in γDL-B. | |||
| †Present in C-strains of HVS. | |||
| ‡Different DNA polymerase III genes (EBERs, EBV; uRNAs, HVS and HVA; tRNAs, MHV-68). | |||
| CCP, complement control protein; DHFR, dihydrofolate reductase; EBERs, Epstein-Barr virus early RNAs; EBNA, Epstein-Barr virus encoded nuclear antigen; EBV, Epstein-Barr virus; EHV-2, equine herpesvirus 2; FGARAT, N-formylgycinamide ribotide amidotransferase; FLIP; FLICE inhibitory protein; GCR, G protein coupled receptor; HHV-8, human herpesvirus 8; HVA, herpesvirus ateles; HVS, herpesvirus saimiri; IE, immediate–early; IL, interleukin; IRF, interferon regulatory factor; LMP, latency membrane protein; LNA, latency nuclear antigen; MDBP, major DNA binding protein; MHV-68, murine herpesvirus 68; OBP, origin binding protein; ORF, open reading frame; Pol., polymerase; RRV, rhesus rhadinovirus; Rta, R transactivator; SAg, superantigen; STP, saimiri transformation associated protein; tip, tyrosine kinase interacting protein; tio, “two-in one” protein; TS, thymidylate synthase. | |||
| MDBP (6) | GCR (βa, γa) | FGARAT (3,75) | STP/K1/R1/Tio/LMP1 |
| Transport protein (7) | Ox-2 (βb, γb) | CCP* (4) (γ2) | Tip†/LMP2/Tio |
| Glycoprotein B (8) | OBP (αa, βb) | Bcl-2** (16) | DHFR (2) (HVS, HHV-8, RRV) |
| DNA polymerase (9) | Chemokines (βb, γb) | Rta (50) | IE1 (12) (HVS, HVA) |
| Major capsid protein (25) | TS (αb, γb) | FLIP (71) | IE/SAg (14) (HVS, HVA) |
| Terminase (29) | Cyclin-D* (72) (γ2) | CD59 (15) (HVS) | |
| Phosphotransferase (36) | LNA (73)/EBNA1 | IL-6 (HHV-8, RRV) | |
| Alkaline exonuclease (37) | EBNA2 (γ1) | Chemokines (HHV-8, RRV) | |
| Helicase-primase (40, 41, 44, 56) | GCR*** | IRFs (HHV-8, RRV) | |
| Uracil DNA glycosylase (46) | Ox-2 (HHV-8, RRV) | ||
| dUTPase (54) | IL-10 (EBV, EHV-2) | ||
| M transactivator (57) | Serpin (MHV-68) | ||
| Processivity factor (59) | Semaphorin (MHV-68) | ||
| Ribonucleotide reductase (61) | Pol. III RNAs‡ (EBV, HVS, MHV-68, HVA) | ||
| Large tegument protein (64) | |||
