Table 2
Characterisation of the latent membrane protein 1 (LMP-1) gene and promoter in Epstein-Barr virus (EBV) isolates from patients with Hodgkin's disease (HD) and infectious mononucleosis (IM)
| Group A–D | Xho-I | Repeat region | 30 bp deletion | Number of cases | |
|---|---|---|---|---|---|
| Group A–D, grouping of the isolates based on sequence analysis of the LMP-1 gene and part of the promoter of sequenced isolates (groups A–D as defined in the result section). | |||||
| Xho-I, presence (+) or loss (–) of the Xho-I restriction site. | |||||
| Repeat region, the number of perfect 33 bp repeats in the LMP-1 repeat region; + indicates a repeat region identical to the prototype EBV strain B95.8.11 | |||||
| 30 bp deletion, absence (–) or presence (+) of the 30 bp deletion (del-LMP-1). | |||||
| *These cases contained additional mutations affecting the Xho-I restriction site or contained the 30 bp deletion (one case with a unique 12 bp deletion) but otherwise had a pattern of single base mutations similar to group A or group B. | |||||
| UG, ungrouped cases. | |||||
| HD | A | + | 4+ | – | 9 |
| A | + | 3, 6 | – | 2 | |
| A* | – | 4+ | – | 1 | |
| A* | + | 4+ | + | 1 | |
| B | + | 4–6 | – | 3 | |
| B* | – | 4, 5 | – | 4 | |
| B* | + | 5 | + | 1 | |
| B* | + | 5 | 12 bp | 1 | |
| C | + | 3–6 | + | 10 | |
| D | – | 3 | – | 1 | |
| UG | + | 4+ | – | 1 | |
| IM | A | + | 4+ | – | 2 |
| B | + | 6 | – | 1 | |
| C | + | 5, 6 | + | 3 | |
| D | – | 2–4 | – | 3 | |
| UG | – | 5 | + | 1 | |
