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Mol Path 53:313-319 doi:10.1136/mp.53.6.313

Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation

Table 3

Tumours lacking concordance between fluorescence in situ hybridisation (FISH) and comparative genomic hybridisation (CGH)

FISH 17p % cells with FISH 17q % cells with FISH 17p status FISH 17q status CGH
Tumour Loss Balance Gain FISH 17p average signal Loss Balance Gain FISH 17q average signal >Threshold Average signal >Threshold Average signal 17p loss 17q gain 17 gain
Equivocal indicates that no value is greater or equal to the threshold of 41%, or that more than one value crosses this threshold.
*i(17q) by FISH.
§i(17q) by CGH.
8 46 46 8 0.85 18 41 41 1.30 Equivocal Balance Equivocal Gain Yes Yes No§
17 78 20 2 0.64 12 35 53 1.38 Loss Loss Gain Gain* No Yes No
19 72 24 4 0.67 7 61 32 1.17 Loss Loss Balance Balance Yes Yes No§
2 70 25 5 0.75 30 38 32 1.08 Loss Loss Equivocal Balance No No No
9 19 69 12 1.02 22 64 14 1.02 Balance Balance Balance Balance No Yes Yes
18 27 44 29 1.05 16 42 42 1.19 Balance Balance Equivocal Balance No Yes Yes

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