Table 4

Mutational analysis of multiple carcinoma in situ lesions surrounding an invasive ductal carcinoma (patient 22)

Lesion	Pathology	Exon	Mutation	bp	Codon	Result
Pathology: DCIS, ductal carcinoma in situ; IDC, infiltrating ductal carcinoma; Intermediate, morphological features of LCIS and DCIS; LCIS, lobular carcinoma in situ.
del., deletion.
1	DCIS	6	9 bp del., insert T	786–794	262–265	Early stop
2	DCIS
3	LCIS
4	Intermediate
5	DCIS	6	9 bp del., insert T	786–794	262–265	Early stop
6	LCIS
7	Intermediate	6	9 bp del., insert T	786–794	262–265	Early stop
8	LCIS
9	Intermediate
10	Intermediate	6	9 bp del., insert T	786–794	262–265	Early stop
11	DCIS
12	DCIS	6	CCC → CTC	779	260	Pro → Leu
		6	9 bp del., insert T	786–794	262–265	Early stop
13	IDC	6	9 bp del., insert T	786–794	262–265	Early stop

Disparate E-cadherin mutations in LCIS and associated invasive breast carcinomas

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