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Mol Path 54:155-159 doi:10.1136/mp.54.3.155

The molecular basis of allergenicity: comparative analysis of the three dimensional structures of diverse allergens reveals a common structural motif

Table 1

Examples of potential remote homologues of Der p 1 determined by PROPSEARCH and tested by examining their three dimensional structures and multiple sequence alignments

ID Description 3D coordinates
Hydrolytic enzymes
pa21_matbi Phospholipase A2 isozyme I 1POB (HSSP)
ctrp_penmo Chymotrypsin (EC 3.4.21.1) 1AZZ (HSSP)
Enzyme inhibitors
iaac_horvu α-Amylase/trypsin inhibitor 1BIP (HSSP)
rag1_orysa Seed allergenic protein RAG 1 precursor 1HSS (HSSP)
Regulatory proteins
prof_enthi Profilin 1YPR (HSSP)
Toxins
scx9_mesma Toxin BMK-IX precursor 1LQQ (HSSP)
sscx3_ortsc Neurotoxin OS3 1LQQ (HSSP)
scx3_butom Neurotoxin III 1LQQ (HSSP)
scx5_cenno Toxin CNGT II precursor 2SN3 (HSSP)
Antibacterial/antifungal proteins
pis1_carpi Bacteriocin pisciolin 126 3LEU (HSSP)
thhr_horvu Antifungal protein (fragment) 1AUN (HSSP)
defi_prote Insect defensins A and B 1ICA (PDB)
defi_anoga Defensin precursor 1ICA (PDB)
afp2_rapsa Cysteine rich antifungal protein 1AYJ (PDB)

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