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Mol Path 54:300-306 doi:10.1136/mp.54.5.300

Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features

Table 1

3p loss of heterozygosity (LOH), together with grade, lymph node status, progesterone receptor (PR) status, and oestrogen receptor (ER) status

LOH (number) Retention (number)
Any locus on 3p
The results show an association between 3p LOH and increasing tumour grade, although this is not significant. There was no correlation between LOH and lymph node status. There was a significant correlation between loss of PR and ER expression (PR, p = 0.0098; ER, p = 0.0472) and loss at any 3p locus.
Grade
1 2 6
2 11 10
3 8 3
Lymph node status
14 11
+ 7 7
p = 0.7496 (NS)
Hormone receptor PR
9 1
+ 10 15
p = 0.0098
Hormone receptor ER
7 1
+ 12 15
p = 0.0472

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