Table 1
Linear growth response of children with Laron syndrome treated by means of insulin-like growth factor 1 (IGF-1)
| Authors | Year | Ref. | N | At start | Growth velocity (cm/year) Year of treatment | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age range (years) | BA (years) | Ht SDS (m) | IGF-1 dose (μg/kg/day) | 0 | 1st | 2nd | 3rd | ||||
| Growth velocity values are mean (SD). | |||||||||||
| *The younger children had a growth velocity of 5.5 and 6.5 cm/year. | |||||||||||
| BA, bone age; b.i.d., twice daily; CA, chronological age; i.d., once daily; Ht SDS, height standard deviation score. | |||||||||||
| (n = 26) | (n = 18) | ||||||||||
| Ranke et al | 1995 | 61 | 31 | 3.7–19 | 1.8–13.3 | −6.5 | 40–120 b.i.d. | 3.9 (1.8) | 8.5 (2.1) | 6.4 (2.2) | |
| (n = 5) | (n = 5) | (n = 1) | |||||||||
| Backeljauw et al | 1996 | 62 | 5 | 2–11 | 0.3–6.8 | −5.6 | 80–120 b.i.d. | 4.0 | 9.3 | 6.2 | 6.2 |
| (n = 9) | (n = 6) | (n = 5) | |||||||||
| Klinger and Laron | 1995 | 63 | 9 | 0.5–14 | 0.2–11 | −5.6 | 150–200 i.d | 4.7 (1.3) | 8.2 (0.8) | 6 (1.3) | 4.8 (1.3)* |
| (n = 15) | (n = 15) | (n = 6) | |||||||||
| Guevarra-Aguirre et al | 1997 | 64 | 15 | 3.1–17 | 4.5–9.3 | 120 b.i.d. | 3.4 (1.4) | 8.8 (11) | 6.4 (1.1) | 5.7 (1.4) | |
| (n = 8) | (n = 8) | ||||||||||
| Guevarra-Aguire et al | 64 | 8 | 80 b.i.d. | 3.0 (1.8) | 9.1 (2.2) | 5.6 (2.1) | |||||
