The aetiology of idiopathic Parkinson's disease
- 1Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
- 2Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China
- 3School of Biochemistry, University of Birmingham
- Dr Ramsden D.B.Ramsden{at}bham.ac.uk
- Accepted 8 March 2001
Abstract
Agents potentially involved in the aetiology of idiopathic Parkinson's disease are discussed. These include factors regulating dopaminergic neurogenesis (Nurr 1, Ptx-3, and Lmx1b) and related proteins, together with genes involved in familial Parkinson's disease (α synuclein, parkin, and ubiquitin carboxy terminal hydroxylase L1), and endogenous and environmental agents.
- Parkinson's disease
- environmental agents
- transcription factors
- α synuclein
- parkin
- ubiquitin carboxy terminal hydroxylase L1
