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Mol Path 54:419-426 doi:10.1136/mp.54.6.419

Multiple system atrophy: cellular and molecular pathology

Table 1

Immunocytochemical characteristics of glial cytoplasmic inclusions in multiple system atrophy 51, 56

Positive immunoreactivity Negative immunoreactivity
*Glial cytoplasmic inclusions are generally negative for phosphate dependent tau antibodies and positive for normal adult tau.
α-Synuclein Tau*
Ubiquitin Neurofilaments
αB-crystallin Glial fibrillary acidic protein
α-Tubulin and β-tubulin Myelin basic protein
Mitogen activated protein 2 Vimentin
Mitogen activated protein 5 Actin
Cyclin dependent kinase 5 Desmin
Mitogen activated protein kinase Myosin
Midkine Cytokeratin
Rab5
Rabaptin-5

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