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Mol Path 55:73-79 doi:10.1136/mp.55.2.73
  • Review

Methods of molecular analysis: mutation detection in solid tumours

Table 1

Mutations can vary by eight orders of magnitude

Scale Nature
<0.1 bp Methylation (5methylC → C)
1 bp Transitions, transvertions (A → G, C → T, etc)
1–10 bp Deletions, insertions, deletion–insertions
10–102 bp Deletions, insertions, invertions, duplications
102–103 bp Whole exon(s) ±intron(s)
103–105 bp Whole gene
106–107 bp Contiguous arrays of genes
107–108 bp Segments/whole chromosomes

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