p21: prognostic marker in pleural mesothelioma
Mesothelioma stained with monoclonal antibody to p21. (A) Mixed mesothelioma with ≤10% of positive cells; (B) sarcomatoid mesothelioma with >10% positive cells. Original magnification ×400.
Expression of p21—an inhibitor of the cell cycle—may hold an important clue to events leading to malignant mesothelioma. Normally p21 expression is upregulated by the binding of …
