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Mol Path 55:300-304 doi:10.1136/mp.55.5.300
  • Original Article

Expression of proteinases and inhibitors in human breast cancer progression and survival

Table 1

Differences in the staining scores of proteinases and inhibitors in each cell type of 44 breast tumours as assessed by immunohistochemistry

Tumour cells Fibroblasts Inflammatory cells
Values are mean (range). *p<0.05; Wilcoxon signed rank test for related samples.
MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinases; tPA, tissue-type plasminogen activator; uPA, urokinase-type plasminogen activator.
MMP-1 1.8 (1–4)* 1.3 (1–3) 1.1 (1–3)
MMP-2 2.3 (1–4)* 1.5 (1–2) 1.3 (1–2)
MMP-3 1.6 (1–4)* 1.2 (1–3) 1.1 (1–3)
MMP-9 1.6 (1–3) 1.6 (1–4) 1.3 (1–4)
uPA 2 (1–4) 1.7 (1–4) 1.2 (1–2)
tPA 1.7 (1–4)* 1.5 (1–3) 1.2 (1–3)
TIMP-1 2.9 (1–4)* 1.9 (1–4) 1.5 (1–4)
TIMP-2 3.2 (1–4)* 2.1 (1–4) 2.1 (1–4)

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