Table 1
Pathohistological data and INK4a-ARF alterations
| p14 alterations | p16 alterations | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Patient No | Sex (M/F) | Tumour size diameter (cm) | RE-PCR | MSP | EXP | RE-PCR | MSP | EXP | Allelic status |
| RE-PCR, restriction enzyme related-polymerase chain reaction; MSP, methylation specific PCR; EXP, gene mRNA expression analysed by reverse transcription PCR; ND, not detected (wild-type, both allels expressed as defined by multiplex PCR); NI, not informative. | |||||||||
| 1 | F | 2.5 | — | — | +++ | +++ | +++ | — | ND |
| 2 | F | 4.9 | — | — | +++ | — | — | +++ | ND |
| 3 | F | 10.5 | — | — | +++ | — | — | +++ | ND |
| 4 | M | 5.5 | — | — | +++ | — | — | +++ | ND |
| 5 | F | 6.5 | — | — | +++ | — | — | +++ | ND |
| 6 | F | 3.0 | — | — | +++ | — | — | +++ | ND |
| 7 | F | 12.5 | — | — | +++ | — | — | +++ | ND |
| 8 | F | 7.6 | — | — | +++ | — | — | +++ | ND |
| 9 | M | 8.0 | — | — | +++ | — | — | +++ | NI |
| 10 | F | 8.5 | — | — | +++ | — | — | +++ | ND |
| 11 | F | 10.8 | +++ | +++ | — | — | — | +++ | ND |
| 12 | F | 4.5 | — | — | +++ | — | — | +++ | ND |
| 13 | F | 14.0 | — | — | +++ | — | — | +++ | NI |
| 14 | F | 10.5 | — | — | +++ | — | — | +++ | ND |
| 15 | F | 9.5 | — | — | +++ | — | — | +++ | ND |
| 16 | F | 8.2 | +++ | +++ | — | — | — | +++ | ND |
| 17 | F | 7.5 | — | — | +++ | — | — | +++ | ND |
| 18 | F | 9.6 | — | — | +++ | +++ | +++ | — | ND |
| 19 | M | 8.3 | — | — | +++ | — | — | +++ | ND |
| 20 | F | 7.8 | — | — | +++ | — | — | +++ | ND |
| 21 | F | 3.9 | — | — | +++ | +++ | +++ | — | ND |
| 22 | F | 9.0 | — | — | +++ | +++ | +++ | — | ND |
| 23 | F | 6.5 | — | — | +++ | +++ | +++ | — | ND |
| 24 | F | 10.2 | +++ | +++ | — | — | — | +++ | ND |
| 25 | F | 7.8 | — | — | +++ | +++ | +++ | — | ND |
