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Mol Path 2003;56:24 doi:10.1136/mp.56.1.24
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Nuclear inclusions go missing from neurones in hereditary ataxias

Mystery surrounding the events leading to degeneration of neurones in hereditary ataxias has deepened, as an immunohistochemical study discloses complete absence of nuclear inclusions in Purkinje cells in human brain stems. At least two opposing explanations are possible.

Nuclear inclusions are of interest because they are usually common in …

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