Table 3
Summary of various mutations seen in 30 carcinomas of the ampulla of Vater
| Patient | Increased cyclin D1 expression | Intracellular β catenin expression | CTNNB-1 mutation | k-ras mutation (codon 12) |
|---|---|---|---|---|
| WT, wild-type gene. | ||||
| 1 | − | − | WT | GGT to GAT (Gly to Asp) |
| 2 | − | − | WT | GGT to GTT (Gly to Val) |
| 3 | − | − | WT | WT |
| 4 | − | − | WT | WT |
| 5 | − | − | WT | WT |
| 6 | − | − | WT | WT |
| 7 | − | − | WT | WT |
| 8 | − | − | WT | WT |
| 9 | − | − | WT | WT |
| 10 | − | − | WT | WT |
| 11 | − | − | WT | WT |
| 12 | − | − | WT | WT |
| 13 | − | − | WT | WT |
| 14 | + | − | WT | GGT to GAT (Gly to Asp) |
| 15 | + | − | WT | GGT to GAT (Gly to Asp) |
| 16 | + | − | WT | GGT to GAT (Gly to Asp) |
| 17 | + | − | WT | GGT to GAT (Gly to Asp) |
| 18 | + | − | WT | GGT to GTT (Gly to Val) |
| 19 | + | − | WT | WT |
| 20 | + | − | WT | WT |
| 21 | + | − | WT | WT |
| 22 | + | + | Codon 37 TCT to TTT (Ser to Phe) | GGT to GTT (Gly to Val) |
| 23 | + | + | Codon 37 TCT to TGT (Ser to Cys) | WT |
| 24 | + | + | Codon 41 ACC to GCC (Thr to Ala) | WT |
| 25 | + | + | Codon 45 TCT to CCT (Ser to Pro) | GGT to GAT (Gly to Asp) |
| 26 | + | + | WT | GGT to GAT (Gly to Asp) |
| 27 | + | + | WT | GGT to GAT (Gly to Asp) |
| 28 | + | + | WT | GGT to GTT (Gly to Val) |
| 29 | + | + | WT | WT |
| 30 | + | + | WT | WT |
